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Mitochondrial-Derived Peptide · Performance, metabolic health, and mitochondrial function.
MOTS-C is a 16-amino-acid peptide encoded in the mitochondrial DNA. It was only identified in 2015 and is one of a small class of mitochondrial-derived peptides that regulate metabolic homeostasis at the cellular level.
MOTS-C improves insulin sensitivity, enhances glucose uptake into cells, and boosts mitochondrial function — the cellular process that produces energy. It activates AMPK, a key metabolic sensor, which improves how the body uses fuel during exercise and at rest. Levels of naturally circulating MOTS-C decline with age.
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Best For |
Metabolic health, athletic performance plateaus, insulin sensitivity, stubborn fat loss, age-related metabolic decline, and endurance athletes. |
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Dosage |
5–10 mg three times per week, administered subcutaneously. Some protocols use 10 mg twice per week with similar outcomes. |
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Protocol |
Run in 4-week cycles with a 2–4 week break between cycles. Effects on body composition and endurance typically become noticeable by week three. |
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Stacks With |
Pairs well with NAD+ for longevity and energy protocols, and with Tesamorelin for body recomposition. |
Well tolerated with few reported side effects. May cause mild fatigue in the first week as the body adapts. Reconstituted MOTS-C should be kept refrigerated.
10mg / 40mg
Metabolism
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