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Nicotinamide Adenine Dinucleotide · A foundational coenzyme for longevity, cognition, and cellular energy.
NAD+ is not strictly a peptide — it is a coenzyme present in every living cell. It is fundamental to mitochondrial function, DNA repair, and cellular energy production. NAD+ levels decline sharply with age, and low NAD+ is associated with many hallmarks of ageing.
NAD+ works as a cofactor for enzymes called sirtuins and PARPs, which regulate DNA repair and cellular longevity pathways. Direct supplementation raises intracellular NAD+ levels more reliably than oral precursors like NR or NMN, particularly via subcutaneous or intravenous delivery.
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Best For |
Longevity protocols, cognitive performance, sustained energy, recovery from extended stress or illness, and individuals over 40 looking to support cellular health. |
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Dosage |
Subcutaneous: 100–300 mg once or twice per week. Intravenous: 500–1000 mg per session, typically weekly or fortnightly for a loading phase, then monthly for maintenance. |
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Protocol |
Ongoing protocol rather than a cycled one. Many users start with a loading phase (weekly doses for 4–6 weeks) then drop to a maintenance schedule. |
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Stacks With |
Pairs well with MOTS-C for metabolic longevity protocols and with GHK-Cu for aesthetic longevity stacks. |
Subcutaneous injection can sting more than other peptides and often benefits from slower administration. IV delivery in a clinic is more comfortable but requires professional oversight. Flushing and warmth during administration are common and harmless.
500mg
Longevity
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