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Triple Receptor Agonist · The most powerful peptide-based weight management tool currently in clinical trials.
Retatrutide is a next-generation injectable that activates three metabolic receptors simultaneously — GLP-1, GIP, and glucagon. It is the successor to the GLP-1-only class (semaglutide, tirzepatide) and is currently in late-stage clinical trials.
GLP-1 activation suppresses appetite and slows gastric emptying. GIP activation enhances insulin sensitivity. Glucagon activation increases energy expenditure. Together, they produce weight loss outcomes that exceed current GLP-1-only options — trial data has shown participants losing up to 24% of body weight.
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Best For |
Significant fat loss, metabolic syndrome, appetite regulation, and individuals who have not responded adequately to diet and exercise alone or to single-agonist GLP-1 medications. |
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Dosage |
Weekly titration protocol — start at 0.25 mg per week for four weeks, increase in 0.25–0.5 mg increments every four weeks based on tolerance. Target doses are typically 4–12 mg per week. |
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Protocol |
Ongoing protocol with regular clinical check-ins. Titration up is essential to minimise gastrointestinal side effects. Maintenance doses can often be reduced once target weight is achieved. |
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Stacks With |
Usually run as a standalone. Can be combined with Tesamorelin for accelerated body recomposition, but this should only be under medical supervision. |
Requires clinical oversight. Most common side effects are nausea, constipation, and fatigue during titration. Should not be used during pregnancy or by individuals with a personal or family history of medullary thyroid cancer.
10mg
Fat Loss
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